Vascular Endothelial Growth Factor A

The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.

Also Known As:

Vascular Endothelial Growth Factor; VEGF; GD-VEGF; Glioma-Derived Vascular Endothelial Cell Growth Factor; VEGF-A; Vascular Permeability Factor; Vasculotropin; Glioma Derived Vascular Endothelial Cell Growth Factor; Permeability Factor, Vascular; Vascular Endothelial Growth Factor-A

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Intercellular Signaling Peptides and Proteins: 30151
    - Angiogenic Proteins: 410
      - Vascular Endothelial Growth Factors: 644
        Vascular Endothelial Growth Factor A: 47084
- Peptides: 84029
  - Intercellular Signaling Peptides and Proteins: 30151
    - Angiogenic Proteins: 410
      - Vascular Endothelial Growth Factors: 644
        Vascular Endothelial Growth Factor A: 47084
Biological Factors: 2560
- Intercellular Signaling Peptides and Proteins: 30151
  - Angiogenic Proteins: 410
    - Vascular Endothelial Growth Factors: 644
      - Vascular Endothelial Growth Factor A: 47084

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Disease

Drug/Important Bio-Agent (IBA)